Breakthrough in Epilepsy Treatment
A 13-year-old boy from Somerset, UK, has become the first patient worldwide to trial a new device implanted in his skull to control severe epilepsy. The neurostimulator, which sends electrical signals deep into his brain, has reduced Oran Knowlson’s daytime seizures by 80%, significantly improving his quality of life.
Life-changing surgery
Oran, who suffers from Lennox-Gastaut syndrome, underwent surgery in October 2023 at Great Ormond Street Hospital in London. His mother, Justine, told the BBC, “He is happier and has a much better quality of life.”
The Picostim neurostimulator, developed by UK company Amber Therapeutics, emits constant electrical pulses to block abnormal brain signals that cause seizures. Unlike previous devices placed in the chest, this neurostimulator is implanted directly in the skull, reducing potential complications like infections and device failure.
Expert insights
Consultant paediatric neurosurgeon Martin Tisdall led the surgical team, inserting electrodes into Oran’s brain with precision and accuracy. “This study aims to determine whether deep brain stimulation is an effective treatment for severe epilepsy,” Tisdall said, noting the benefits of the skull-mounted device for children.
Post-operation progress
Post-surgery, Oran has shown remarkable improvement, with no daytime seizures and reduced severity of nighttime seizures. He can recharge the device daily via wireless headphones while engaging in activities he enjoys, such as watching TV and taking riding lessons.
The trial, part of the CADET project, involves several prestigious institutions, including University College London and King’s College Hospital. Three more children with Lennox-Gastaut syndrome will be fitted with the neurostimulator. Future developments aim to make the device respond in real time to brain activity changes, potentially blocking seizures before they occur.
Justine expressed optimism about the next phase: “The Great Ormond Street team gave us hope back…now the future looks brighter.” Although the treatment is not a cure, Oran’s family remains hopeful that he will continue to improve.
The Picostim neurostimulator has also shown promise in treating Parkinson’s disease, and similar skull-mounted devices are being used in the United States for epilepsy treatment.